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Stephen Safe Selected Research

Member 2 Group A Nuclear Receptor Subfamily 4

10/2015A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro.
12/20081,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.

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Stephen Safe Research Topics

Disease

147Neoplasms (Cancer)
06/2022 - 03/2002
72Breast Neoplasms (Breast Cancer)
05/2021 - 01/2002
51Pancreatic Neoplasms (Pancreatic Cancer)
05/2022 - 09/2002
38Colonic Neoplasms (Colon Cancer)
01/2021 - 09/2004
18Neoplasm Metastasis (Metastasis)
01/2022 - 11/2005
17Carcinogenesis
01/2022 - 07/2004
13Inflammation (Inflammations)
01/2020 - 01/2011
12Prostatic Neoplasms (Prostate Cancer)
01/2018 - 06/2002
9Lung Neoplasms (Lung Cancer)
06/2022 - 01/2009
9Rhabdomyosarcoma
12/2021 - 02/2013
8Parkinson Disease (Parkinson's Disease)
10/2020 - 11/2009
8Urinary Bladder Neoplasms (Bladder Cancer)
01/2016 - 01/2006
6Leukemia
01/2017 - 12/2005
5Liver Neoplasms (Liver Cancer)
01/2022 - 01/2003
5Endometrial Neoplasms (Endometrial Cancer)
01/2021 - 06/2002
4Glioblastoma (Glioblastoma Multiforme)
10/2020 - 01/2019
4Skin Neoplasms (Skin Cancer)
10/2016 - 01/2013
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
12/2021 - 01/2009
3Ovarian Neoplasms (Ovarian Cancer)
01/2021 - 09/2006
3Obesity
01/2019 - 01/2014
3Insulin Resistance
02/2016 - 06/2012
3Hepatocellular Carcinoma (Hepatoma)
09/2015 - 11/2004
3Weight Loss (Weight Reduction)
09/2015 - 11/2010

Drug/Important Bio-Agent (IBA)

84Proteins (Proteins, Gene)FDA Link
01/2022 - 08/2002
44Sp Transcription FactorsIBA
10/2021 - 03/2007
42Pharmaceutical PreparationsIBA
10/2020 - 03/2002
36LigandsIBA
12/2021 - 06/2002
29Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
01/2022 - 06/2002
27Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
06/2022 - 07/2005
25SurvivinIBA
05/2022 - 03/2007
25Estrogens (Estrogen)FDA Link
10/2021 - 06/2002
24Messenger RNA (mRNA)IBA
01/2020 - 08/2002
24Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2016 - 02/2004
23PPAR gammaIBA
06/2010 - 03/2003
21Estrogen Receptor alphaIBA
06/2010 - 01/2002
19Antineoplastic Agents (Antineoplastics)IBA
04/2021 - 03/2002
18Cyclin D1IBA
11/2016 - 03/2003
16Orphan Nuclear ReceptorsIBA
05/2022 - 03/2010
16Transcription Factors (Transcription Factor)IBA
10/2021 - 05/2003
16Hormones (Hormone)IBA
10/2020 - 06/2002
16Polychlorinated Dibenzodioxins (TCDD)IBA
01/2020 - 06/2002
15Estrogen ReceptorsIBA
01/2021 - 06/2002
15Reactive Oxygen Species (Oxygen Radicals)IBA
11/2019 - 08/2010
14Cytochrome P-450 CYP1A1 (CYP1A1)IBA
01/2021 - 01/2004
133,3'-diindolylmethane (diindolylmethane)IBA
01/2018 - 04/2006
12tolfenamic acidIBA
02/2014 - 06/2006
11indoleIBA
06/2022 - 10/2008
9TriterpenesIBA
10/2021 - 03/2007
9Member 1 Group A Nuclear Receptor Subfamily 4IBA
04/2021 - 09/2010
9methyl 2- cyano- 3,11- dioxo- 18beta- olean- 1,12- dien- 30- oateIBA
01/2020 - 05/2007
9MicroRNAs (MicroRNA)IBA
04/2015 - 02/2006
91,1- bis(3'- indolyl)- 1- (4- t- butylphenyl)methaneIBA
09/2011 - 09/2004
8ErbB Receptors (EGF Receptor)IBA
12/2021 - 05/2010
81,1- bis(3'- indolyl)- 1- (4- hydroxyphenyl)methaneIBA
11/2019 - 09/2010
8Proteasome Endopeptidase Complex (Proteasome)IBA
12/2018 - 10/2002
8Betulinic AcidIBA
11/2016 - 03/2007
8rat MIRN27 microRNAIBA
12/2015 - 11/2007
7PhytochemicalsIBA
04/2021 - 11/2007
7LuciferasesIBA
01/2020 - 02/2004
7Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
02/2014 - 06/2006
7Caveolin 1IBA
05/2010 - 09/2004
6Proto-Oncogene Proteins c-metIBA
05/2021 - 07/2009
6Omeprazole (Prilosec)FDA LinkGeneric
07/2020 - 11/2012
6CurcuminIBA
01/2018 - 07/2008
6Glutathione (Reduced Glutathione)IBA
08/2017 - 10/2005
5RNA (Ribonucleic Acid)IBA
01/2019 - 08/2002
5Metformin (Glucophage)FDA LinkGeneric
01/2018 - 12/2013
5AntioxidantsIBA
08/2017 - 05/2008
4Biological ProductsIBA
01/2021 - 03/2007
4CarcinogensIBA
01/2021 - 03/2004
4Phosphotransferases (Kinase)IBA
01/2020 - 12/2005
4CytokinesIBA
01/2020 - 01/2014
4Glycyrrhetinic Acid (Po 12)IBA
01/2019 - 05/2007
4Hypoglycemic Agents (Hypoglycemics)IBA
01/2018 - 12/2013
4AcidsIBA
01/2017 - 11/2007
4TamoxifenFDA LinkGeneric
01/2012 - 06/2002
46-methyl-1,3,8-trichlorodibenzofuranIBA
01/2012 - 04/2004
4Estrogen Receptor Modulators (Antiestrogen)IBA
11/2008 - 05/2003
3ResveratrolIBA
06/2022 - 05/2008
3FlavonoidsIBA
12/2021 - 01/2018
3celastrolIBA
10/2021 - 04/2012
3Tryptophan (L-Tryptophan)FDA Link
10/2020 - 10/2015
3Transforming Growth Factors (Transforming Growth Factor)IBA
01/2020 - 05/2016
31,1- bis(3'- indolyl)- 1- (4- chlorophenyl)methaneIBA
01/2020 - 12/2008
3Leflunomide (Arava)FDA LinkGeneric
05/2018 - 11/2012
3Flutamide (Eulexin)FDA LinkGeneric
05/2018 - 07/2014
31- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
01/2018 - 02/2015
3Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/2018 - 01/2011
3indole-3-carbinolIBA
02/2017 - 10/2008
3tranilastIBA
02/2017 - 07/2014
3bardoxolone methylIBA
01/2017 - 07/2005
3Hydroxyl RadicalIBA
01/2017 - 03/2004
3NF-kappa B (NF-kB)IBA
11/2016 - 08/2002
3Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
05/2016 - 07/2005
3Sulindac (Copal)FDA LinkGeneric
12/2015 - 11/2012
3DioxinsIBA
09/2015 - 06/2003

Therapy/Procedure

22Drug Therapy (Chemotherapy)
06/2022 - 11/2005
10Therapeutics
01/2021 - 06/2002
6Chemoprevention
12/2020 - 06/2012
4Aftercare (After-Treatment)
01/2018 - 10/2002